The recommended starting dose of Estrace is 2 to 4 grams once a day for 1 to 2 weeks. It’s important to wash the applicator with mild soap and warm water after every use.Įstrace cream is usually started at a higher dose and lowered over a period of a few weeks. Both medications are inserted into the vagina with a reusable applicator. The way you apply Estrace and Premarin is similar, but the recommended doses are different.
